Use of the National Cancer Institute Community Cancer Centers Program screening and accrual log to address cancer clinical trial accrual.

Posted: Mar 24, 2014
J Oncol Pract. 10. 2. e73-e80.
KEYWORDS: Level of Clinical Trials Knowledge or Awareness, Institutional Issues, Eligibility, Older Adults, Minority Groups, Cancer

Highlights

Screening logs help sites identify barriers and address problems of accrual in real time.

Why this item may be useful

A web-based screening log was successfully incorporated into the workflow of 29 community cancer centers across 22 states. The log was used to identify and overcome local system-based barriers to accrual. The value was that the information was available real time and sites could tailor solutions specific to their local issues. Sites also found the log to be a beneficial tool for assessing their accrual performance on individual trials, managing their portfolio of trials, understanding their demographics, and assessing staff performance in patient recruitment. The sites also felt that the Log aided them in providing accurate data reports to cancer committees, multidisciplinary conferences, and accrediting bodies. In addition to serving as a valuable local resource, the aggregated log data informed study chairs about trial-wide accrual barriers that might be addressed and mitigated. 

 

Details

  • 5000 log entries for 27 clinical trials, from March 2009 through May 2012, were analyzed. 
  • The log fields included: demographics, screening method, whether the patient enrolled, and if not, provider or patient's reasons for nonenrollment or reasons for ineligibility
  • No statistical difference was seen in enrollment rates between elderly and the young, Hispanic and non-Hispanic, or between white and black races. However, patients of other races had significantly lower enrollment rates than either blacks or whites. 
  • Over half the reasons for patient and physician declining a trial were related to lack of desire to participate or preference for standard of care.